A partnership between UW and WSU

Washington Center for Muscle Biology

research . training . discovery . treatment

Rodgers lab

Repairing damaged muscle, whether skeletal or cardiac, is fundamentally important to treating many muscular dystrophies and many types of heart failure.  The Rodgers laboratory is determining how hormones and other chemical messengers regulate myogenesis and more importantly, how controlling it with gene or stem cell therapeutics will develop better treatments.

Attenuating the actions of MYOSTATIN is at the core of their research.  As its name implies (“myo” for muscle & “statin” for inhibitor), myostatin is a muscle-specific hormone that negatively regulates muscle growth.  Inhibiting the inhibitor, therefore, increases the mass and functional capacity of both skeletal and cardiac muscle.  The Jekyll mouse lacks the gene for myostatin, is double muscled and its stem cells glow green after drinking a “secret formula”.  What else would you name it, Mr. Hyde?  The mouse is helping scientists determine exactly how myostatin regulates muscle stem cells (pictured, mature muscle cells derived from stem cells) and will be instrumental in developing novel therapeutics for treating many muscle related diseases.  In fact, the Rodgers laboratory is currently testing a new gene therapy that can significantly enhance muscle growth by blocking myostatin action inside the cell.  This approach is highly specific and has a much reduced potential for causing unwanted side effects.

Intrigued?  Curious?  Interested in supporting this research?  The Rodgers lab wants to hear from you.

  1. deweer said on August 10, 2016:

    très intéressé par vos recherches

  2. Terry Colella said on August 9, 2016:

    Your image at the top – the Jekyll mouse –
    the word “therapies” is misspelled.

    Currently it your site spells it as therepies
    which is not correct.

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Washington Center for Muscle Biology, ASLB 124, Department of Animal Sciences, Pullman WA 99164, 509-335-2991, Contact Us
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